Rare Side Effect of Diphenhydramine
several people have reported experiencing involuntary muscle contractions , twitches , jerks , or spasms —especially around falling asleep—after taking diphenhydramine (commonly known as Benadryl or used in sleep aids like Nytol or ZzzQuil). This matches what you're describing: muscle contractions in limbs or back that partially wake you up, combined with dizziness or grogginess. Why This Happens Diphenhydramine is a first-generation antihistamine with strong anticholinergic effects, which can influence the central nervous system and sometimes lead to: Muscle twitching Restlessness Myoclonic jerks (sudden, brief involuntary contractions) Exaggerated hypnic jerks (normal "sleep starts" that occur as you drift off, but intensified) These are not the most common side effects (drowsiness, dry mouth, and dizziness are more typical), but they are documented in medical literature, drug side effect databases, and user reports. Evidence from Reports and Sources User ...